To reinforce the point that the 'desmo' singles (at the time) were pretty much a marketing tool by Ducati to sell more bikes, in my experience there really is no performance difference between a 'good' road going valve spring single and its 'desmo' variant. Well set up a std.road going 'desmo' engine is mechanically quieter and with an open megga a 250/350 is no more than about 5mph or so faster than a comparable road going valve spring engine. While in theory the 'desmo' engine is mechanically capable of revving to much higher figures than the valve spring motor thus producing more power, the whole thing falls apart (no pun intended

) with the small bore rubbish VHB carb, the silentium silencer, and the fact that if you could achieve sustained high rpm it will result in the crankshaft limitations becoming destructively apparent. I have stashed away a perfect rebuilt 'desmo' head for my 350mk3 with a view to building a 350 'desmo' replica at some time......but I was only ever going to do it for aesthetic reasons not for performance.
I have pulled down quite a few Ducati single valve spring engines (mostly badly abused) and at worst a new cam and rockers will sort the head out.......thrashed 'desmo' heads are a very expensive mess! I would say a 'desmo' head on your Ducati single (whilst alluring

) is about as useful as an ashtray on the handlebars

.............Just my experience and opinion, others may disagree
Cheers, George